Tailor-made notched music training: double-blind RCT (negative on primary)
Record details
- Authors: Stein A, et al.
- Journal / source: BMC Neurology (2016)
- Design: Double-blind RCT, notched music 2 h/day × 3 months vs placebo; ISRCTN04840953
- Sample: 100
- Primary endpoint: THQ + VAS (loudness/awareness/distress/handicap)
- Randomized: Yes · Sham/placebo-controlled: Yes · Independent of the manufacturer: Yes
What this research found
NO significant effect on any primary outcome. A late secondary loudness reduction at follow-up is hypothesis-level only.
The key independent non-replication of Okamoto 2010's notched-music effect at 12× the sample size.
Limitations and conflicts of interest
3-month treatment window.
Funding / conflicts: Independent.
Primary sources
Used as evidence for
This is an original summary from the Tinnitus Evidence verified database, checked against the primary source — not a reproduction of the publisher's abstract.