First US real-world Lenire cohort (Communications Medicine)
Record details
- Authors: McMahan E, Lim HH, et al.
- Journal / source: Communications Medicine (Nature Portfolio) (2025)
- Design: Retrospective real-world cohort
- Sample: 212 fitted / 220 enrolled
- Primary endpoint: THI change
- Randomized: No · Sham/placebo-controlled: No · Independent of the manufacturer: No
What this research found
91.5% responder rate; mean THI improvement 27.8 points — open-label, uncontrolled real-world data.
First of two US chart reviews (the second is Kasper 2026, Am J Audiol).
Limitations and conflicts of interest
Uncontrolled; retrospective.
Funding / conflicts: Manufacturer-linked.
Primary sources
Used as evidence for
This is an original summary from the Tinnitus Evidence verified database, checked against the primary source — not a reproduction of the publisher's abstract.