Melatonin for tinnitus: randomized double-blind crossover

Record details

Authors: Hurtuk A, et al.
Journal / source: Annals of Otology, Rhinology & Laryngology (2011)
Design: Randomized double-blind placebo-controlled crossover; melatonin 3 mg nightly × 30 days
Sample: 61
Primary endpoint: Tinnitus matching and self-rated tinnitus scores
Randomized: Yes · Sham/placebo-controlled: Yes · Independent of the manufacturer: Yes

What this research found

Significantly greater decreases in tinnitus matching and self-rated tinnitus vs placebo (p<0.05), plus improved sleep. Small, short crossover — a signal, not an established therapy.

Outcomes mix intensity-matching and self-rating (not THI-based). Greatest effect reported in men, bilateral tinnitus, and those without prior depression/anxiety. Guidelines still recommend against supplements as a class.

Limitations and conflicts of interest

N=61 crossover; 30-day exposure; non-standard outcomes.

Funding / conflicts: Independent.

Primary sources

Used as evidence for

Supplements (ginkgo, zinc, melatonin…)

This is an original summary from the Tinnitus Evidence verified database, checked against the primary source — not a reproduction of the publisher's abstract.