Pharmacotherapy for subjective tinnitus: network meta-analysis of 60 RCTs
Record details
- Authors: Li P, Che C, Wu Y, et al.
- Journal / source: BMJ Open (2025)
- Design: Systematic review + network meta-analysis (>30 drug interventions)
- Sample: 60 RCTs
- Primary endpoint: Various
- Randomized: Yes · Sham/placebo-controlled: Yes · Independent of the manufacturer: Yes
What this research found
No approved drug exists; 78% of included studies had methodological concerns; evidence quality low to very low. Tentative signals (antioxidants, GABA agonists) are hypothesis-generating only and conflict with Cochrane.
Limitations and conflicts of interest
Garbage-in problem: weak underlying trials.
Funding / conflicts: Independent.
Primary sources
Used as evidence for
This is an original summary from the Tinnitus Evidence verified database, checked against the primary source — not a reproduction of the publisher's abstract.