The Research Behind Tinnitus Evidence
Every research record in the Tinnitus Evidence database — trials, systematic reviews, guidelines and regulatory records — each verified against its primary source, with design, results, limitations and conflicts of interest. Negative and failed results are first-class records here, not footnotes.
Randomized & controlled trials (37)
- Smartphone tinnitus app: double-blind sham-controlled RCT (Japan) (2026)
- MOST trial: modified sound therapy, 4-arm double-blind RCT (DFCRS arm) (2025)
- Oto app RCT vs waitlist (Flinders University) (2025)
- UNITI-RCT: single versus combined treatments for chronic tinnitus (2025)
- MindEar (Tinnibot) chatbot CBT: pilot RCT (2024)
- EEG neurofeedback for tinnitus: randomized trial of opposite protocols (2023)
- Kalmeda app (mobile CBT-based therapy): RCT behind Germany's DiGA listing (2023)
- CBT for insomnia in tinnitus-related insomnia: RCT (2023)
- OTO-313 (intratympanic gacyclidine) Phase 2: negative trial (2023)
- Bimodal stimulation using vibration on the skin (Neosensory Duo) (2023)
- Reversing synchronized brain circuits using targeted auditory-somatosensory stimulation (bisensory device RCT) (2023)
- Internet-based audiologist-guided CBT for tinnitus: US randomized controlled trial (2022)
- Systematic evaluation of the T30 neurostimulator (acoustic CR): double-blind randomized placebo-controlled trial (2022)
- Supervised physical therapy added to treatment for somatic tinnitus (2022)
- Prototype digital polytherapeutic for tinnitus: randomized single-blind controlled trial (2022)
- TENT-A2: different bimodal neuromodulation settings in a large randomized trial (2022)
- Notched music vs ordinary music: independent RCT (2021)
- TENT-A1: bimodal sound + tongue stimulation for tinnitus (2020)
- Caudate deep brain stimulation for treatment-resistant tinnitus: Phase 1 (2019)
- QUIET-1: AUT00063 (Kv3 modulator) Phase 2a — stopped early for futility (2019)
- TRTT: Tinnitus Retraining Therapy vs standard of care (2019)
- Auditory-somatosensory bimodal stimulation desynchronizes brain circuitry (first human pilot) (2018)
- Keyzilen (AM-101) TACTT2 & TACTT3 Phase 3 failures (registry records) (2018)
- rTMS for chronic tinnitus: multicenter randomized sham-controlled trial (negative) (2017)
- Tinnitus-matched sound during sleep (Levo): randomized trial (2017)
- Mindfulness-based cognitive therapy for chronic tinnitus: RCT (2017)
- Vagus nerve stimulation paired with tones: randomized double-blind pilot (2017)
- Cervical physiotherapy for somatic (cervicogenic) tinnitus: RCT (2016)
- Tailor-made notched music training: double-blind RCT (negative on primary) (2016)
- rTMS for chronic tinnitus: VA randomized sham-controlled trial (positive) (2015)
- CBT for hyperacusis: randomized controlled trial (adjacent evidence) (2014)
- Specialised CBT-based stepped care vs usual care (largest CBT trial) (2012)
- Melatonin for tinnitus: randomized double-blind crossover (2011)
- Neramexane for tinnitus: Phase 2 miss and unpublished Phase 3 program (2011)
- Tailor-made notched music: proof-of-concept (loudness reduction) (2010)
- Neuromonics third clinical trial (two active variants, no control) (2007)
- Gabapentin for tinnitus: randomized double-blind trial (negative) (2007)
Systematic reviews & meta-analyses (21)
- Pharmacotherapy for subjective tinnitus: network meta-analysis of 60 RCTs (2025)
- rTMS for tinnitus: meta-analysis of 16 RCTs (2025)
- Cochlear implantation and tinnitus: systematic review and meta-analysis (2024)
- Sigmoid sinus wall reconstruction for venous pulsatile tinnitus: pooled outcomes (2024)
- Venous sinus stenting for pulsatile tinnitus: pooled analysis of 28 studies (2024)
- Transcutaneous auricular vagus nerve stimulation for tinnitus: systematic review with meta-analysis (2023)
- Acceptance and Commitment Therapy for tinnitus: meta-analysis (2023)
- Acupuncture for tinnitus: umbrella review of systematic reviews (2022)
- Ginkgo biloba for tinnitus (Cochrane Review) (2022)
- Global prevalence and incidence of tinnitus: systematic review and meta-analysis (2022)
- Transcranial electrical stimulation for tinnitus: meta-analysis (2022)
- Acupuncture for tinnitus: systematic review and meta-analysis (8 RCTs) (2021)
- Cognitive behavioural therapy for tinnitus (Cochrane Review) (2020)
- Low-level laser therapy for tinnitus: meta-analysis with trial sequential analysis (2020)
- Betahistine for tinnitus (Cochrane Review) (2018)
- Sound therapy (amplification devices and sound generators) for tinnitus (Cochrane Review) (2018)
- Zinc supplementation for tinnitus (Cochrane Review) (2016)
- Cochrane: amplification with hearing aids for tinnitus (CD010151) (2014)
- Cochrane: antidepressants for tinnitus (CD003853) (2012)
- Hyperbaric oxygen for idiopathic sudden hearing loss and tinnitus (Cochrane Review) (2012)
- Cochrane: anticonvulsants for tinnitus (CD007960) (2011)
Clinical guidelines (3)
Company programs & registry records (3)
Measurement standards & context records (5)
- Sex-specific association of tinnitus with suicide attempts (population-based) (2019)
- COMiT'ID: core outcome domains for tinnitus treatment trials (2018)
- Diagnostic criteria for somatosensory tinnitus: international Delphi consensus (2018)
- Tinnitus Functional Index (TFI): development and validation (2012)
- Tinnitus Handicap Inventory (THI): development (1996)